Endocrine Abstracts

Introduction: Thyrotropin-secreting pituitary adenomas are rare tumors accounting for 1–2% of all pituitary adenomas and the diagnosis is based on the combination of high fT4 levels with normal to high TSH concentration in the presence of a pituitary adenoma. About one third co-secrete other hormones, of which, most frequently growth hormone (16%) followed by prolactin and gonadotropins.Case report: A 60 years-old male patient presented in 2016 afte...

Introduction: Inappropriate secretion of TSH, despite elevated levels of T4, is due to either a TSH-secreting adenoma (TSHoma) or thyroid hormone resistance (RTH). RTH is a rare disorder, usually caused by mutations in the thyroid hormone receptor beta, characterized by a variable tissue hyporesponsiveness to thyroid hormone. The increased level of TSH may predispose to thyrotroph hyperplasia and possible adenoma formation.Case report: A 21 years old fem...